Ultraviolet Radiation-Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging

Ultraviolet Radiation-Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging

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Skin is the largest human organ.Skin continually reconstructs itself to ensure its viability, integrity, and ability to provide protection for the body.Some areas of skin are continuously exposed to a variety of environmental stressors that can inflict direct and indirect damage to skin cell DNA.Skin homeostasis is maintained by mesenchymal stem cells in inner layer The use of plant waste to ensure the functioning of agricultural energy complexes dermis and epidermal stem cells (ESCs) in the outer layer epidermis.

Reduction of skin stem cell number and function has been linked to impaired skin homeostasis (e.g., skin premature aging and skin cancers).Skin stem cells, with self-renewal capability and multipotency, are frequently affected by environment.

Ultraviolet radiation (UVR), a major cause of stem cell DNA damage, can contribute to depletion of stem cells (ESCs and mesenchymal stem cells) and damage of stem cell niche, eventually leading to photoinduced skin aging.In this review, we discuss the role of UV-induced DNA damage and oxidative stress in the skin stem cell aging in order to gain insights into the pathogenesis and Assessing the Genetic Diversity of Ilex guayusa Loes., a Medicinal Plant from the Ecuadorian Amazon develop a way to reduce photoaging of skin cells.